Its high level of safety makes it attractive as an agent for long-term use in these chronic disorders. PCH appeared to have an additive effect relative to use of calcitonin alone.Ĭollagen hydrolysate is of interest as a therapeutic agent of potential utility in the treatment of osteoarthritis and osteoporosis. Studies of the effects of calcitonin with and without a collagen hydrolysate-rich diet suggested that calcitonin plus PCH had a greater effect in inhibiting bone collagen breakdown than calcitonin alone, as characterized by a fall in levels of urinary pyridinoline cross-links. Given the important role for collagen in bone structure, the effect of PCH on bone metabolism in osteoporotic persons has been evaluated. This preferential uptake by cartilage suggests that PCH may have a salutary effect on cartilage metabolism. Preferential accumulation of 14C-labeled gelatin hydrolysate in cartilage as compared with administration of 14C-labeled proline has been reported. In addition, increased efficacy for PCH as compared to placebo was observed in the overall study population amongst patients with more severe symptomatology at study onset. There was, however, a significant treatment advantage of PCH over placebo in German sites. In a multicenter, randomized, doubleblind, placebo-controlled trial performed in clinics in the United States, United Kingdom, and Germany, results showed no statistically significant differences for the total study group (all sites) for differences of mean pain score for pain. Clinical use is associated with minimal adverse effects, mainly gastrointestinal, characterized by fullness or unpleasant taste. Clinical studies suggest that the ingestion of 10 g PCH daily reduces pain in patients with osteoarthritis of the knee or hip blood concentration of hydroxyproline is increased. Pharmaceutical-grade collagen hydrolysate (PCH) is obtained by hydrolysis of pharmaceutical gelatin. Hydrolyzed gelatin products have long been used in pharmaceuticals and foods these products are generally recognized as safe food products by regulatory agencies. Review of past and current literature relative to collagen hydrolysate metabolism, and assessment of clinical investigations of therapeutic trials in osteoarthritis and osteoporosis. Gelatin is used in foods, personal care products, medications and other medical products. Other names for gelatin, including trade names, are listed here and here. To review the current status of collagen hydrolysate in the treatment of osteoarthritis and osteoporosis. Gelatin can also be listed on labels as hydrolyzed collagen, hydrolyzed animal protein, collagen hydrolysate, denatured collagen, and gelatina.
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